Bradley H. Strauss

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Recent Research Projects

MR-Guided Management of Occlusive Peripheral Arterial Disease

2018/19 • $158,355 • PI,CO
Occlusive peripheral arterial disease occurs when blockages in blood vessels limit the blood supply to the leg. This disease is widespread and represents a major societal burden. Approximately 20% of those over the age of 59 years suffer from this disease, which results in over 160,000 limb...

MR-Guided Revascularization of Occlusive Peripheral Arterial Disease

2012/13-2017/18 • $562,215 • PI,CO
Occlusive peripheral arterial disease occurs when blockages in blood vessels limit the blood supply to the leg. This disease is widespread and represents a major societal burden. Approximately 20% of those over the age of 59 years suffer from this disease, which results in over 160,000 limb...

Longitudinal study of microvascular pathology as a multi-systemic phenotype underlying early atherosclerosis risk and neurocognition in bipolar disorder

2017/18 • $100,000 • PI,CO
An American Heart Association Scientific Statement positioned bipolar disorder (BD) as a condition that predisposes youth to excessive and premature heart disease. Importantly, the increased risk of heart disease in BD is above-and-beyond what can be explained by traditional heart disease risk...

Catheter Based Ultrasound Mediated Collagenase Therapy for the Treatment of Chronic Total Occlusions

2016/17 • $100,000 • PI,CO
Blockages of the coronary or femoral arteries begin as soft blood clots but over time they can harden becoming what are called chronic total occlusions (CTOs). In the heart, patients can often survive the formation of CTOs but have degraded lifestyles and reduced life expectancies due to poor...

Improving the Assessment and Treatment of Severe Aortic Stenosis by Evaluating Care Gaps and Advancing Risk Predictions

2011/12 • $100,000 • PI,CO
Aortic stenosis is the most common form of valvular heart disease in Canada. It is currently estimated that 5% of people > 75 years old have this condition. The prevalence of aortic stenosis is increasing rapidly because of our aging society. Aortic stenosis is a deadly condition since once...

CIHR team in occlusive vascular disease

2010/11 • $331,500 • PI,CO
Many people suffer from total blockages or occlusions in arteries supplying the heart and leg muscles. Surgeries to bypass the blockages can reduce disability and extend life, but they have significant associated risks, so are not even considered for many patients. Less invasive methods where...

Therapeutic Strategies for Chronic Total Occlusion Revascularization

2010/11 • $159,100 • PI,CO
Chronic (>1 month) total occlusions (CTO) in the coronary arteries are common, cause significant anginal symptoms and likely contribute to decreased survival. Since angioplasty success rates are markedly decreased in CTO (approximately 50% or worse), patients are usually referred for more...

A Phase 1, First-in-Man Trial of Intracoronary Collagenase Therapy For Chronic Total Occlusions

2010/11 • $139,338 • PI
Coronary arteries that have been totally blocked for 6 weeks or longer, are called chronic total occlusions (CTO). CTO are found in 30% of all coronary angiograms and frequently cause significant cardiac symptoms (such as chest pain and shortness of breath), and likely contribute to decreased...

Microvascular Injury in Acute Myocardial Infarction

2010/11 • $100,000 • PI,CO
It is well known that treatment of an acute heart attack with balloon angioplasty saves lives and decreases the size of the heart attack. Balloon angioplasty restores blood flow in the artery that has caused the heart attack due to an acute complete blockage with blood clot. Unfortunately even...

Patents

CATHETER DEVICE FOR LUMEN RE-ENTRY AND METHODS FOR USE THEREOF

A catheter device for lumen re-entry is provided. The catheter device includes a catheter shaft having a lumen extending from a proximal end to a distal end and an expandable member positioned at the distal end of the catheter shaft. The catheter shaft having interior walls defining a central lumen extending from a proximal end to a distal end along a longitudinal axis of the lumen. The expandable member configured to receive a fluid that selectively expands the expandable member from a...
Related applications: WO2018CA51124