Cindi M. Morshead

Contact via University of Toronto

Key Research Areas
Associated Researchers
Associated Organizations

Recent Research Projects

Polymeric Biomaterials for Applications in Medicine

2015/16-2019/20 • $2,140,739 • PI,Other
Overarching Direction of Research ProgramTo design biomaterials solutions to unsolved problems in medicine. To influence cell fate through local and targeted delivery strategies and engineered three-dimensional (3D) hydrogel microenvironments. We will design novel injectable hydrogels for local...

Investigating the niche-dependent regulation of regionally distinct endogenous neural stem cells in the forebrain and spinal cord by myelin basic protein

2019/20 • $35,000 • Scholarship/Fellowship,Other
Myelin basic protein (MBP) is a major protein constituent of the myelin sheath expressed by oligodendrocytes of the central nervous system (CNS). Its canonical function is to enable the adhesion of multilayered compact myelin throughout the CNS for improved saltatory conduction. We have recently...

Promoting neural regeneration with stem cell based therapies: A novel source of autologous human neural stem cells for transplantation

2014/15-2018/19 • $1,250,000 • PI,CO
While the promise of stem cells is real, the reality of stem cell based therapies is limited by an incomplete understanding of the multitude of interactions required for successful transplantation therapies. The most significant challenge is identifying the ideal cell type that should be...

Promoting cognitive recovery using endogenous neural stem cell activation and rehabilitation following stroke

2012/13-2017/18 • $992,394 • PI,CO
Stroke is the leading cause of permanent neurological disability in Canada with over 50,000 new cases annually. There are no current medical therapies for alleviating the chronic functional impairments following stroke. The identification of multipotent neural stem cells in the adult mammalian...

The isolation and characterization of a novel population of neural stem cells in the adult brain.

2012/13-2017/18 • $569,444 • PI
Neurogenesis, the process of generating functional neurons from precursor cells, was traditionally thought only to occur during embryonic development. It is now well established that active neurogenesis occurs into adulthood. The neurogenic cells are derived from neural stem cells (NSCs) that...

Endogenous Repair Strategies to Treat Childhood Brain Injury

2015/16-2016/17 • $105,000 • Scholarship/Fellowship,Other
Treatment for brain tumors in children typically involves a combination of surgery, radiation therapy and chemotherapy. While these treatment strategies lead to increased survival, they can also lead to long-term cognitive impairment in these patients that greatly impact their quality of life....

CIHR Training Program in Regenerative Medicine

2010/11-2014/15 • $1,625,000 • PI,CO
Organ failure is a pervasive medical problem that results in immense personal and economic costs, morbidity, and death. At present, the only truly effective treatment for organ failure is transplantation. The deficiencies of this option are increasingly apparent, and include a chronic shortage...

Bioengineered cell delivery system

2011/12-2013/14 • $344,130 • PI,CO
Traumatic spinal cord injury is often described in terms of the primary injury, which results from a mechanical insult such as a motor vehicle or sports-related accident, and the secondary injury, which results in a cascade of events, resulting in an inhibitory environment. The latter limits...

Wnt Signaling Promotes Symmetrical of Division of Adult Neural Stem Cells in vitro and in vivo.

2010/11-2011/12 • $70,000 • Scholarship/Fellowship,Other
The adult mammalian brain contains a small population of stem cells. Due to their 2 fundamental properties: that they are able to divide indefinitely and that they can give rise to all the cell types that make up the brain, stem cells hold enormous potential for the treatment of brain trauma and...

In-vivo monitoring of neural recovery following stem-cell therapies in an animal model of stroke

2010/11 • $168,275 • PI
Stroke is the number one cause of disability in adults. Yet, despite of this, no medical treatments can fully restore brain function and reverse the deficits. Promising results from animal studies show that significant brain regeneration after stroke is possible. We will test two novel stroke...