Bojana Stefanovic



Key Research Areas
Associated Researchers
Associated Organizations

Recent Research Projects

Enhancing vascular remodeling in Alzheimer's disease following covert stroke

2015/16-2020/21 • $1,071,999 • PI,CO
By age 85, one out of every two Canadians will suffer from a stroke, dementia or both. Covert or sub-clinical stroke that typically comprises many small brain vessels yet results in no clinical symptoms is a major risk factor for both overt stroke and dementia. It often develops gradually years...

Promoting neurovascular recovery following focal ischemic stroke

2016/17-2020/21 • $872,113 • PI,CO
In the healthy brain, neurons, glia, and vessels work in concert so that blood flow adjusts in proportion to the level of neuronal activity. In stroke, a blockage of a major artery results in a sharp decline in blood flow, damaging the neurons and inducing sudden paralysis, impaired speech,...

Contribution of Mid-life Comorbidities to Alzheimer's Disease

2017/18-2020/21 • $822,625 • PI,CO
About a quarter of middle aged Canadians are hypertensive and mounting evidence suggests these people are at a risk of exacerbated AD progression. The percentage of male/female hypertensive Canadians is equivalent in 45-65 aged individuals however more women develop late life AD suggesting that...

Small Vessel Disease meets protein misfolding: Phenobanking common dementias in clinical care to inform future precision medicine.

2018/19-2020/21 • $815,099 • PI,CO,Other
Dementia is a syndrome that affects your memory, thinking, and behavior, resulting in significant burden to your family, friends, and overall, the Canadian health-care system. In addition to Alzheimer's disease, there are many causes of dementia, which are often overlapping, complex, and...

Imaging of cerebral vascular adaptation following traumatic brain injury

2017/18-2020/21 • $747,269 • PI,CO
The blood vessels that supply the brain with oxygen and nutrients form a complex and highly organized network whose proper functioning is essential for our survival. Disease or injury to the brain may damage this network and disrupt the transport of blood and the mechanisms that regulate how...

Transdifferentiation of astrocytes into neurons to improve neuronal network function in Alzheimer's disease.

2018/19-2020/21 • $579,448 • PI
Progressive cognitive decline associated with amyloid deposition, neurofibrillary tangles, and neurodegeneration is hallmark of Alzheimer's disease (AD). The cognition impairment in both patients and in rodent models of Alzheimer's disease is related to temporal modulation of neuronal signaling...

Modulating peri-ischemic neuronal hyperexcitability

2018/19-2020/21 • $569,949 • PI,CO
In the healthy brain, neuronal functioning depends on continual tuning of blood flow in proportion to the level of local neuronal activity. A blockage of a major artery during stroke results in a sharp decline in blood flow, killing the neurons and inducing sudden paralysis, impaired speech,...

Long-term effects of mild traumatic brain injury through premature cellular senescence

2019/20-2020/21 • $413,559 • PI
Mild traumatic brain injury (mTBI) or concussions are very common, and tend to occur frequently in contact sports. They are also very common in situations of domestic abuse, in the military and can be a concern in certain work-places such as factories and construction sites. Recurrent mTBI has...

Neuroimaging

2019/20-2020/21 • $400,000 • PI
Dr. Stefanovic, an international leader in imaging of brain vessels and neurons, is advancing the applications of non-invasive imaging to stroke, Alzheimer¿s Disease, and traumatic brain injury. Her team has elucidated ways in which brain adapts following injury and demonstrated means by which...

Rescuing Neurovascular Network Function with Transcranial Neuromodulation

2020/21 • $113,220 • PI,CO
Stroke is the leading cause of adult neurological disability with most survivors suffering moderate to severe long-term sensorimotor deficits. These are caused by the incomplete remapping of lost function to surviving neurons. To date, the many attempted pharmacological approaches have shown...

Canadian Consortium on Neurodegeneration in Aging - Full Proposal

2014/15-2018/19 • $24,450,000 • PI,CO
The neurodegenerative brain diseases - Alzheimer's Disease, Vascular dementia, Frontotemporal dementia, and Dementia with Lewy Bodies - will be the "diseases of the 21st century" due to aging of our population. The decision by CIHR to establish a Canadian Consortium on Neurodegeneration in Aging...

Cohort to illuminate Neurodegeneration, Genetics, Imaging Associations and Leukoaraiosis (CONGENIAL)

2015/16-2018/19 • $730,343 • PI,CO
For decades, conventional approaches to neurodegenerative research have not paid much attention to the diversity within clinical diagnostic groups when looking at brain-behavior relationships. Analyzing correlations using discrete clinical diagnostic groups is limited as it fails to capture the...

World Congress for Microcirculation 2018 (WCM2018): Microcirculation in health and disease; emerging research and technologies.

2018/19 • $10,000 • PI,CO
The 11th World Congress for Microcirculation (WCM2018, September 9-13th, 2018; Vancouver, BC) is a unique interdisciplinary conference focused on the microcirculation, the system of small vessels that controls perfusion to and within key organs (brain, heart, kidney and skeletal muscle) and...

The mechanism of neurovascular remodelling after focal ischemia

2012/13-2017/18 • $683,373 • PI,CO
In the healthy brain, neurons and blood vessels work in concert so that blood flow increases when neurons become active. This neurovascular coupling is compromised in stroke, whereby a blockage of a major artery results in a sharp decline in blood flow, causing damage to the neurons, and...

Investigation of the bioeffects of blood-brain barrier disruption by focused ultrasound: A multifaceted imaging approach

2012/13-2016/17 • $803,100 • PI,CO
Drug delivery to the brain is limited by the presence of a specialized structure known as the blood-brain barrier (BBB). A recent technology known as focused ultrasound has been shown to successfully open the BBB and allow access of drugs to the brain from the bloodstream. Focused ultrasound...

Mechanisms of Sex Differences in Focal Cerebral Ischemia

2016/17 • $148,466 • PI,CO
Neurons and brain blood vessels work in concert so that blood flow increases when neurons become active. This neurovascular coupling is compromised in stroke, whereby a blockage of a major artery results in a sharp decline in blood flow, causing damage to the neurons, and inducing sudden...

Neurovascular Adaptation

2010/11-2015/16 • $793,339 • PI,CO
The brain responds to not receiving an adequate supply of oxygen by growing more of the small blood vessels that permeate all brain tissue. This process of adding new blood vessels can be induced by prolonged intense exercise or exposure to high altitude (low oxygen) environments. In disorders...

Biophysics of Functional MRI

2010/11-2015/16 • $300,000 • PI
Functional magnetic resonance imaging has greatly enhanced our understanding of how the healthy human brain processes information. To date, however, this technology's promise of revolutionizing clinical practice has not been realized, to a large extent due to the lack of a detailed knowledge of...

Modulation of immune status is necessary for full recovery in Alzheimer's disease

2010/11-2014/15 • $984,134 • PI,CO
Amyloid disorders, such as Alzheimer's disease and vascular dementia, are characterized by loss of CNS homeostasis and neurodegeneration leading to cognitive decline. The common and central feature of these diseases is amyloid deposition, of which the major component is the amyloid beta peptide...

Simultaneous optical imaging of oxygenation and blood flow for chronic monitoring of stroke and seizure activity

2012/13-2014/15 • $270,000 • PI,CO
Patients surviving ischemic stroke often express delayed epileptic syndromes. Late poststroke seizures occur after a latency period lasting from several months to years after the insult. These seizures might result from ischemia-induced neuronal death and associated morphological and...

In Vivo Brain Mapping in the Dementias: A Longitudinal Brain-Behaviour Study with a Focus on Cerebrovascular Disease and Heterogeneity

2014/15 • $100,000 • PI,CO
The prospect of disease-modifying therapies in the pipeline for Alzheimer's Disease (AD) has intensified efforts to use brain imaging more effectively for diagnosis and monitoring of dementing illnesses. There is also emerging awareness of the destructive interplay between AD and Cerebrovascular...

In Vivo Brain Mapping in the Dementias: A Longitudinal Brain-Behaviour Study With a Focus on interactions of Alzheimer's and Cerebrovascular Disease

2010/11-2013/14 • $987,738 • PI,CO
The prospect for disease-modifying therapies for Alzheimer~s Disease (AD) has intensified efforts to find brain imaging changes that will help in screening, differential diagnosis, monitoring disease course and response to new interventions. In this rapidly moving field, longitudinal studies are...

Multimodal Imaging of Structure and Function Changes Associated with Leukoaraiosis

2011/12-2013/14 • $105,000 • Scholarship/Fellowship,Other
Brain lesions in the tissue responsible for transmitting brain signals that appear bright on magnetic resonance imaging (MRI) images are referred to as white matter hyper-intensities (WMH). They are found in 25% of healthy individuals over the age of 65 and have been linked to dementia. In the...

Imaging Functional Recovery in Stroke

2012/13-2013/14 • $105,000 • Scholarship/Fellowship,Other
Over 50,000 strokes occur in Canada each year: 15% are lethal, making stroke the 3rd leading cause of death. Out of the 300,000 Canadians living with the effects of stroke, half suffer from moderate to severe impairments. That the rehabilitation of this patient population is not more effective...

Towards functional imaging biomarkers of Alzheimer's Disease

2010/11-2012/13 • $203,012 • PI,CO
Alzheimer's Disease (AD) is the most common single cause of dementia. Progress towards new treatments for AD has led to an effort to find biological markers of the disease, which may aid in diagnosis, tracking, and predicting response to drug treatment. Functional brain imaging, where measures...

Biophysics of Functional MRI

2010/11-2011/12 • $184,176 • PI,CO
Functional magnetic resonance imaging has greatly enhanced our understanding of how the healthy human brain processes information. To date, however, this technology's promise of revolutionizing clinical practice has not been realized, to a large extent due to the lack of a detailed knowledge of...

Patents