Recent Research Projects

Cathepsin Z as a novel master regulator of chronic inflammation in the brain and lung.

2017/18-2019/20 • $520,965 • PI
Multiple sclerosis (MS) is an incurable, severely debilitating disease with suboptimal therapy and no cure. Canada has the highest incidence of MS in the world with 291 cases per 100,000 people. MS is most commonly diagnosed in young adults and patients suffer progressive and irreversible damage...

Central and peripheral determinants of acute and persistent joint pain

2016/17-2019/20 • $393,716 • PI,CO
Pain with motion, pain at rest, pain at night, sharp pain, dull pain-pain is highly variable among and within those afflicted with arthritis. Much is now known about joint tissue changes in arthritis, but only a little is known about how pain that begins in the joint makes its way to the spinal...

Role of neuroinflammation in the development of chronic joint pain

2016/17-2019/20 • $378,429 • PI,CO
Chronic joint pain is a common cause of disability that is difficult to treat effectively and is poorly understood. The symptoms of chronic pain reported by arthritis patients closely resemble those reported by patients with nerve injuries. This suggests that arthritis pain might be caused, at...

Exploration of global control mechanisms of endosomal and phagosomal chemistries and their consequences to macrophage and dendritic cell function in health and disease.

2012/13-2017/18 • $300,000 • PI
Macrophages and dendritic cells are cells of the immune system known as phagocytes (meaning "eating cells"). They are named for their ability to engulf particulate material by a process called phagocytosis. Following phagocytosis, the engulfed material is broken down within compartments known as...

Exploration of global control mechanisms of endosomal and phagosomal chemistries and their consequences to macrophage and dendritic cell function in health and disease.

2010/11-2015/16 • $610,090 • PI
Macrophages and dendritic cells are cells of the immune system known as phagocytes (meaning "eating cells"). They are named for their ability to engulf particulate material by a process called phagocytosis. Following phagocytosis, the engulfed material is broken down within compartments known as...

Patents