Gerald W. Zamponi


Contact via University of Calgary


Key Research Areas
Associated Researchers
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Recent Research Projects

Voltage gated calcium channels: molecular targets for pain therapeutics

2015/16-2019/20 • $2,666,214 • PI
Chronic pain is a debilitating condition that reflects a long term sensitization of signal transduction in the afferent pain pathway. We now know that this process involves the dysregulation of voltage-gated calcium channels – key players that control the neuronal activity along the pain...

Molecular Neuroscience

2017/18-2019/20 • $450,000 • PI
No summary

Central mechanisms of opioid withdrawal

2019/20 • $100,000 • PI,CO
Opioid medications provide potent pain relief in the short-term, but their long-term use can cause serious adverse effects. A major problem is that chronic opioid users experience debilitating withdrawal symptoms when attempting to stop or reduce their opioid medications. In an attempt to curb...

Quantitative imaging of fluorescent Cav3.2 T-type calcium channel biosensor: a novel tool for studying processing of pain signals.

2018/19-2019/20 • $86,667 • Scholarship/Fellowship,Other
The proper communication between neurons is an important determinant of nervous system function. Malfunction in the communication system between nerve cells can lead to a number of disorders, including chronic pain. Chronic pain is a prevalent problem and it is considered a debilitating...

Molecular Neuroscience

2010/11-2017/18 • $1,400,000 • PI
Voltage- and ligand-gated calcium channels are important players in the regulation of calcium entry into neurons under both physiological and pathophysiological conditions. Our laboratory uses a combination of state of the art experimental approaches to examine how these calcium channels are...

Regulation of synaptic processing by a Cav3-Kv4 ion channel complex

2012/13-2017/18 • $1,118,189 • PI,CO
The brain is able to process information because ion channels that drive electrical activity provide the means for cells to communicate. All communication takes place at synaptic junctions, where ion channels can modulate incoming signals. This research project will examine signal processing in...

Dysregulation of T-type channel trafficking in inflammatory and neuropathic pain

2014/15-2015/16 • $149,179 • PI
Chronic pain can be a debilitating condition for which there are currently few treatment options, leading to a major burden on our Health care system and the Canadian economy due to lost productivity. We have discovered a previously unrecognized mechanism that contributes to the development of...

Signaling complexes between G protein coupled receptors and N-type calcium channels

2010/11-2014/15 • $1,041,950 • PI
Calcium plays a number of highly important roles in human physiology. In the brain, calcium entering into nerve cells controls nerve to nerve communication and triggers a variety of intracellular signaling processes. At the same time, too much calcium is toxic, and hence, the amount of calcium...

Molecular physiology of T-type calcium channels

2010/11-2014/15 • $872,384 • PI
Calcium plays a number of highly important roles in human physiology. In the brain, calcium entering into nerve cells controls nerve to nerve communication and triggers a variety of intracellular signaling processes. At the same time, too much calcium is toxic, and hence, the amount of calcium...

T type calcium and A type potassium current interactions

2010/11-2012/13 • $351,215 • PI,CO
The timing, frequency and pattern of neuronal spike output reflects a delicate balance between inward and outward currents that depend on the properties of voltage- and calcium-dependent ion channels. Any interaction between channels on a molecular or physiological level can greatly increase the...

Cholesterol is a critical component in the mechanism of Ca2+-triggered membrane fusion

2010/11-2011/12 • $220,257 • PI,CO
Secretion, the release of stored compounds, is a fundamental cellular process essential for numerous actions including wound healing, nervous system function and the release of hormones and insulin. Thus, improper functioning of the secretory pathway can lead to serious medical conditions such...

Canada Research Chair in Molecular Neurobiology

2010/11 • $150,000 • PI
Calcium is critical for the proper functioning of the brain. One of the key factors that control calcium entry into nerve cells are voltage-dependent calcium channels. They are implicated in a number of diseases, such as stroke, migraine and epilepsy, and are the targets for clinically active...

Patents