Overcoming antibiotic resistance through the inhibition of aminoglycoside phosphotransferases (APH).
Natural Sciences and Engineering Research Council of Canada
- Grant type: Collaborative Health Research Projects
- Years: 2013/14 to 2014/15
- Total Funding: $169,101
No research areas found.
Multidrug resistant microbes have become one of the top global health challenges and place a massive burden on theCanadian health care system. One approach to overcome this problem involves inhibiting the enzymes responsible forconferring resistance to the antibiotic. We have recently discovered a family of compounds that blocks the action of a seriesof aminoglycoside phosphotransferases (APH) and wish to develop the compounds to ultimately provide an optimized, ontarget, on-mechanism lead suitable for development into a therapeutic agent.