Overcoming antibiotic resistance through the inhibition of aminoglycoside phosphotransferases (APH).

Funding Details

Natural Sciences and Engineering Research Council of Canada

Grant type: Collaborative Health Research Projects
Years: 2013/14 to 2014/15
Total Funding: $169,101

Keywords

No research areas found.

Principle Investigator(s)

Capretta, Alfredo
McMaster University

Collaborator(s)

Savchenko, Alexei
University of Toronto
Wright, Gerard
McMaster University

Partners

Project Summary

Multidrug resistant microbes have become one of the top global health challenges and place a massive burden on theCanadian health care system. One approach to overcome this problem involves inhibiting the enzymes responsible forconferring resistance to the antibiotic. We have recently discovered a family of compounds that blocks the action of a seriesof aminoglycoside phosphotransferases (APH) and wish to develop the compounds to ultimately provide an optimized, ontarget, on-mechanism lead suitable for development into a therapeutic agent.