Inhibitory synaptic pruning as a substrate of neuropathic pain

Funding Details
Canadian Institutes of Health Research
  • Grant type: Project Grant
  • Years: 2019/20 to 2020/21
  • Total Funding: $210,430
Principle Investigator(s)

No partner organizations found.

Project Summary

Chronic pain does not serve any useful purpose and is now considered a disease by itself. Unfortunately, it is often poorly managed in the clinic as we still have a limited knowledge of what causes it. Neuropathic pain is a form of chronic pain that sometimes appears after lesions to nerves and is particularly difficult to treat. Understanding the changes in neuronal connections (synapses) that process sensory information in the spinal cord is essential for developing better treatments. Here we propose that after nerve damage, there is a loss of a specific type of synapse that control pain transmission by inhibiting the hyperactivity of neuronal networks in the spinal cord, and that such loss is mediated by resident immune cells of the nervous system. The detailed mechanisms of this will be investigated in mouse models of neuropathic pain. The information obtained with this research will provide important clues for the development of new approaches to treat chronic pain after nerve lesions. A multidisciplinary approach will be used for these investigations.

Related Projects

The global objective of this project is to develop an in vivo measurement strategy for large-scale monitoring of microlesions that are below the detection limits of magnetic resonance imaging, and identify biomarkers in the pathology of multiple scle... More ...
The future of progress in Life Sciences, from understanding basic biochemistry to complex biological organisms and environmental issues, hinges critically on our ability to improve our ways to study and manipulate molecules and living organisms with ... More ...