Minimally-invasive Drug Delivery Strategy for Acute Spinal Cord Injury Repair

Funding Details
Canadian Institutes of Health Research
  • Grant type: Operating Grant
  • Years: 2010/11 to 2012/13
  • Total Funding: $322,527
Keywords
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Project Summary

After traumatic spinal cord injury, the communication pathway between the brain and the rest of the body (the periphery) deteriorates, resulting in essentially lost function below the site of injury. To promote communication between the brain and the periphery after injury, we are developing a minimally-invasive drug delivery strategy that will release therapeutically relevant molecules over a specified time frame directly to the injured tissue. Using this strategy, the therapeutic molecules will be released at the diseased site and limit the degeneration that normally ensues after injury, while at the same time promoting regeneration. Conventional strategies, such as bolus, minipump / catheter or systemic delivery, are unable to provide prolonged local release. Using our injectable strategy, we aim to reduce and ultimately overcome the devastation that normally occurs after spinal cord injury.

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