High throughput screening identifies SOX2 as a super pioneer factor that inhibits DNA methylation maintenance at its binding sites

Nature Communications, Vol. 12 (2021)

Keywords
Authors
  • Ludovica Vanzan
  • Department of Genetic Medicine and Development, University of Geneva Medical School
  • Hadrien Soldati
  • Department of Genetic Medicine and Development, University of Geneva Medical School
  • Victor Ythier
  • Department of Genetic Medicine and Development, University of Geneva Medical School
  • Santosh Anand
  • Department of Genetic Medicine and Development, University of Geneva Medical School
  • Simon M. G. Braun
  • Department of Genetic Medicine and Development, University of Geneva Medical School
  • Nicole Francis
  • Institut de Recherches Cliniques de Montréal (IRCM) and Département de Biochimie et Médecine Moléculaire, Université de Montréal
  • Rabih Murr
  • Department of Genetic Medicine and Development, University of Geneva Medical School

Abstract

The functional relevance of epigenetic modifications on transcription regulation has been an important question since their discovery. Here, the authors investigate the effect of DNA methylation on Pioneer Transcription Factor (PF) binding and distinguish between PFs that protect their binding sites from methylation and those that bind to methylated DNA and induce DNA demethylation.

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