HOXA13 in etiology and oncogenic potential of Barrett’s esophagus

Nature Communications, Vol. 12 (2021)

Keywords
Authors
  • Vincent T. Janmaat
  • Department of Gastroenterology and Hepatology, Erasmus MC - University Medical Center Rotterdam
  • Kateryna Nesteruk
  • Department of Gastroenterology and Hepatology, Erasmus MC - University Medical Center Rotterdam
  • Manon C. W. Spaander
  • Department of Gastroenterology and Hepatology, Erasmus MC - University Medical Center Rotterdam
  • Auke P. Verhaar
  • Department of Gastroenterology and Hepatology, Erasmus MC - University Medical Center Rotterdam
  • Bingting Yu
  • Department of Gastroenterology and Hepatology, Erasmus MC - University Medical Center Rotterdam
  • Rodrigo A. Silva
  • Department of Gastroenterology and Hepatology, Erasmus MC - University Medical Center Rotterdam
  • Wayne A. Phillips
  • Division of Cancer Research, Peter MacCallum Cancer Centre
  • Marcin Magierowski
  • Department of Gastroenterology and Hepatology, Erasmus MC - University Medical Center Rotterdam
  • Anouk van de Winkel
  • Department of Gastroenterology and Hepatology, Erasmus MC - University Medical Center Rotterdam
  • H. Scott Stadler
  • Department of Skeletal Biology, Shriners Hospital for Children
  • Tatiana Sandoval-Guzmán
  • DFG-Center for Regenerative Therapies, Technische Universität Dresden
  • Luc J. W. van der Laan
  • Department of Surgery, Erasmus MC - University Medical Center Rotterdam
  • Ernst J. Kuipers
  • Department of Gastroenterology and Hepatology, Erasmus MC - University Medical Center Rotterdam
  • Ron Smits
  • Department of Gastroenterology and Hepatology, Erasmus MC - University Medical Center Rotterdam
  • Marco J. Bruno
  • Department of Gastroenterology and Hepatology, Erasmus MC - University Medical Center Rotterdam
  • Gwenny M. Fuhler
  • Department of Gastroenterology and Hepatology, Erasmus MC - University Medical Center Rotterdam
  • Nicholas J. Clemons
  • Division of Cancer Research, Peter MacCallum Cancer Centre
  • Maikel P. Peppelenbosch
  • Department of Gastroenterology and Hepatology, Erasmus MC - University Medical Center Rotterdam

Abstract

Barrett’s esophagus is a pro-oncogenic lesion in the proximal gastrointestinal tract, but with a distal colon-like morphology. Here the authors report that the distal HOX gene HOXA13 is expressed in Barrett’s esophagus and in single cells of the physiological esophagus, and may underlie the phenotypic aspects of metaplasia and increase proliferation.

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