Naked mole-rat brown fat thermogenesis is diminished during hypoxia through a rapid decrease in UCP1

Nature Communications, Vol. 12 (2021)

Keywords
Authors
  • Hang Cheng
  • Department of Biology, University of Ottawa
  • Rajaa Sebaa
  • Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa
  • Nikita Malholtra
  • Department of Biology, University of Ottawa
  • Baptiste Lacoste
  • Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa
  • Ziyad El Hankouri
  • Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa
  • Alexia Kirby
  • Department of Biology, University of Ottawa
  • Nigel C. Bennett
  • Department of Zoology and Entomology, University of Pretoria
  • Barry van Jaarsveld
  • Department of Zoology and Entomology, University of Pretoria
  • Daniel W. Hart
  • Department of Zoology and Entomology, University of Pretoria
  • Glenn J. Tattersall
  • Department of Biological Sciences, Brock University
  • Mary-Ellen Harper
  • Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa
  • Matthew E. Pamenter
  • Department of Biology, University of Ottawa

Abstract

Naked mole-rats are hypoxia-tolerant mammals, and during hypoxia their body temperature decreases via unknown mechanisms. Here the authors report that the hypoxia-induced body temperature decrease in naked mole rats occurs through decreased brown adipose tissue thermogenesis via decreases in a key thermogenic mitochondrial protein: UCP1.

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