The telomere length landscape of prostate cancer

Nature Communications, Vol. 12 (2021)

Keywords
Authors
  • Julie Livingstone
  • Department of Human Genetics, University of California
  • Yu-Jia Shiah
  • Ontario Institute for Cancer Research
  • Takafumi N. Yamaguchi
  • Department of Human Genetics, University of California
  • Lawrence E. Heisler
  • Ontario Institute for Cancer Research
  • Vincent Huang
  • Ontario Institute for Cancer Research
  • Robert Lesurf
  • Ontario Institute for Cancer Research
  • Tsumugi Gebo
  • Department of Human Genetics, University of California
  • Benjamin Carlin
  • Department of Human Genetics, University of California
  • Stefan Eng
  • Department of Human Genetics, University of California
  • Erik Drysdale
  • Ontario Institute for Cancer Research
  • Jeffrey Green
  • Ontario Institute for Cancer Research
  • Theodorus van der Kwast
  • Princess Margaret Cancer Centre, University Health Network
  • Robert G. Bristow
  • Princess Margaret Cancer Centre, University Health Network
  • Michael Fraser
  • Princess Margaret Cancer Centre, University Health Network
  • Paul C. Boutros
  • Department of Human Genetics, University of California

Abstract

Despite the known role of telomere length in cancer, its association with genomic features remains unclear. Here, the authors integrate telomere length, genomics, transcriptomics and proteomics in localized prostate cancer and reveal links between telomere maintenance, disease drivers and clinical outcomes.

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