GlaxoSmithKline

Research Areas
Collaborating Researchers
Collaborating Organizations

Recent Research Projects

Technologies to enable automated manufacturing of validated pharmaceutical hits

2019/20 • $341,643
Development of new drugs is a very slow and expensive undertaking that includes a sequence of risk-prone steps. The ultimate goal of the pharmaceutical industry is to transform early stages of drug development into an automated manufacturing process. The combinatorial approach is arguably the...

Dynamics of cell-to-cell mediated HIV-1 spread in the lymph node

2015/16-2019/20 • $195,833
The human immunodeficiency virus-1 (HIV-1) epidemic has infected approximately 75 million people worldwide, of which more than 35 million have died from acquired immunodeficiency syndrome (AIDS)-related complications. The development of antiretroviral therapy has been a great achievement of...

Better understanding of chronic obstructive pulmonary disease (COPD) and intervention guides

2014/15-2019/20 • $137,500
Chronic obstructive pulmonary disease (COPD) is the 4th cause of mortality and it is projected to move up to the 3rd rank by 2020. Mortality has increased and COPD results in higher rates of hospitalization than heart failure, angina and other chronic diseases. COPD remains under diagnosed and...

Better understanding of chronic obstructive pulmonary disease (COPD) and intervention guides

2014/15-2019/20 • $137,500
Chronic obstructive pulmonary disease (COPD) is the 4th cause of mortality and it is projected to move up to the 3rd rank by 2020. Mortality has increased and COPD results in higher rates of hospitalization than heart failure, angina and other chronic diseases. COPD remains under diagnosed and...

Proteinase-Activated Receptors as a therapeutic target in allergic inflammation

2015/16-2019/20 • $112,500
Asthma affects more than 3 million Canadian, causing significant morbidity and high cost for the health care system. Although we have some excellent medications to treat airway inflammation, the majority of asthmatics remain poorly controlled. Developing a treatment strategy that minimizes...

Novel Type 1 Cannabinoid Receptor Allosteric Modulators

2017/18-2019/20 • $109,375
The type 1 cannabinoid receptor (CB1R) is present at high levels throughout the brain and other parts of the body. CB1R is activated by the body's own cannabinoids (anandamide and 2-arachidonoylglycerol), synthetic cannabinoids, and cannabinoids from marijuana (e.g. THC and cannabidiol). CB1R is...

Dynamics of cell-to-cell mediated HIV-1 spread in the lymph node

2015/16-2019/20 • $83,333
The human immunodeficiency virus-1 (HIV-1) epidemic has infected approximately 75 million people worldwide, of which more than 35 million have died from acquired immunodeficiency syndrome (AIDS)-related complications. The development of antiretroviral therapy has been a great achievement of...

Proteinase-Activated Receptors as a therapeutic target in allergic inflammation

2015/16-2019/20 • $76,500
Asthma affects more than 3 million Canadian, causing significant morbidity and high cost for the health care system. Although we have some excellent medications to treat airway inflammation, the majority of asthmatics remain poorly controlled. Developing a treatment strategy that minimizes...

Therapeutic interventions to impact lung inflammatory responses induced by exposure to environmental pollutants

2015/16-2019/20 • $56,153
Chronic obstructive pulmonary disease (COPD), a term that encompasses a number of diseases such as chronic bronchitis & emphysema, is a progressive inflammatory condition of the lungs predominantly caused by inhalation of ambient pollutants such as cigarette smoke and air pollution. COPD is a...

Epigenetics and Epigenomics of Head and Neck Cancer

2019/20 • $37,500
Cancers of the head and neck are solid tumors arising in the oral cavity, oropharynx, hypopharynx, larynx, and nasopharynx. Unfortunately, there are few biomarkers that can be reliably used either in early detection of this disease, or as indicators of patient outcome. This study will utilize...

The Canadian Respiratory Research Network: Origin and Progression of Airway Disease

2013/14-2018/19 • $4,450,000
The Canadian Respiratory Research Network (CRRN), in close partnership with the Canadian Lung Association (CLA) and other partners, will improve patient care and outcomes through creation of an enduring national network of investigators and research platforms to enable innovative, collaborative,...

Medical Annotation of the Human Genome Sequence

2013/14-2018/19 • $415,177
No summary

Technologies to enable automated manufacturing of validated pharmaceutical hits****

2018/19 • $324,613
Development of new drugs is a very slow and expensive undertaking that includes a sequence of risk-prone steps. The ultimate goal of the pharmaceutical industry is to transform early stages of drug development into an automated manufacturing process. The combinatorial approach is arguably the...

Skeletal muscle dysfunction in COPD

2013/14-2018/19 • $300,000
The muscles from the lower limbs are commonly affected in persons suffering from a chronic respiratory disease. This is important because this may cause exercise intolerance, quality of life and even life expectancy. This is also important because muscles can be treated. The purpose of this...

Medical Annotation of the Human Genome Sequence

2013/14-2018/19 • $276,783
Rapid progress in nanotechnology and information science is bringing whole genome sequencing into the affordable realm to millions of persons and useful for many purposes in health research. Building from the experiences and infrastructure of the first five years of this GSK-CIHR Pathfinder...

Pathogenesis of Hepatitis B Virus Infection in Non-Alcoholic Fatty Liver Disease

2016/17-2018/19 • $248,746
Despite the availability of a safe and effective vaccine, the hepatitis B virus (HBV) afflicts over 240 million people worldwide leading to ~1 million deaths per year from serious liver disease and liver cancer. Over 240,000 Canadians are believed to be infected by hepatitis B. Due to the...

Respiratory health care delivery improvement in airway diseases; asthma, chronic obstructive pulmonary disease and alpha1 antitrypsin deficiency.

2013/14-2018/19 • $175,000
The management of common respiratory diseases such as asthma and COPD (chronic obstructive pulmonary disease including emphysema and chronic bronchitis) is often poor. Professor Chapman's research has shown that typical Canadian patients with asthma have poor control of their disease and suffer...

Epigenetics and Epigenomics of Head and Neck Cancer

2017/18-2018/19 • $71,875
Cancers of the head and neck are solid tumors arising in the oral cavity, oropharynx, hypopharynx, larynx, and nasopharynx. Unfortunately, there are few biomarkers that can be reliably used either in early detection of this disease, or as indicators of patient outcome. This study will utilize...

Technology for high-fidelity podocyte cultivation

2017/18-2018/19 • $71,428
We propose to develop a 3D cell culture system for podocytes in vitro. Podocytes are the primary cell type in the kidney glomerulus that are responsible for blood filtration and waste removal into the urine. Currently, there is a limited ability to study this cell type in vitro because standard...

Sustainable, continuous chemical manufacturing using micro flow reactor technology

2013/14-2017/18 • $2,097,532
Many business sectors have moved production to a 'just-in-time' operation that offers many practicaladvantages that lead to improved efficiency and cost savings. Fine-chemical synthesis, such as the preparationof drugs, may have the most to be gained by moving to such a format and yet chemical...

Influence of motor behaviour on sensory feedback to primary motor cortex

2012/13-2017/18 • $375,000
Humans are able to perform a broad range of motor skills, from the rapid spinning of an elite diver to the precise staccato of a violinist. Recent theories suggest that sensory feedback from the limb (and vision) are essential for performing these voluntary motor skills. In particular, the...

Viral and Human Predictors of Reponses to HIV Therapies

2012/13-2017/18 • $350,000
HIV is a virus that destroys the immune system. If untreated, it typically leads to the fatal disease called AIDS (Acquired Immune Deficiency Syndrome) within 10 years. Over 70,000 Canadians have HIV. HIV infection can be treated with a life-long drug cocktail known as highly active retroviral...

Chair - GlaxoSmithKline Partnered (2012-2013)

2013/14-2017/18 • $350,000
Infectious diseases are the most common cause of death in children worldwide, and also contribute to death, disability and decreased quality of life in people of all ages. The advent of routine vaccine programs has been hailed as one of the most important interventions, other than clean water,...

Mechanism of action of DNMT1 inhibitors; a pharmacoepigenomic analysis

2013/14-2017/18 • $330,000
Our genes that are inherited from our parents are marked by a chemical coating during gestation and are packaged in a highly organized manner in the nucleus of all cells. The chemical coating called "DNA methylation" and the packaging termed "chromatin modification" programs our genes so that...

Influence of motor behaviour on sensory feedback to primary motor cortex

2012/13-2017/18 • $273,670
Humans are able to perform a broad range of motor skills, from the rapid spinning of an elite diver to the precise staccato of a violinist. Recent theories suggest that sensory feedback from the limb (and vision) are essential for performing these voluntary motor skills. In particular, the...

Platform technology for maturation of human stem cell derived cardiomyocytes and cardiotoxicity screening

2016/17-2017/18 • $149,789
Beating heart cell cannot be sampled and expanded from human hearts, thus pharmaceutical industry is forced to usealternative methods to assess safety and efficacy of new drug candidates before they reach humans including assessmentin animal models. Animal heart cells have different functional...

Improving metagenomic inference and sample classification in inflammatory bowel disease

2016/17-2017/18 • $80,000
"Microbiome" is a relatively new term to describe the entire set of microbes and their functions within a particular environment. Researchers are sampling various microbiomes including the ocean, soil, and host-associated (e.g. plant, animal and human). The host-associated microbiomes are...

Do rhinovirus infections contribute to airway remodeling in asthma?

2011/12-2016/17 • $500,000
Infections with the common cold virus (human rhinovirus) are a frequent cause of wheezing illnesses during early childhood. Studies indicate that wheezing illnesses due to human rhinovirus (HRV) infections are associated with an increased risk of developing asthma by the age of 6 years. Asthma...

CIHR/GSK Chair of Diabetes: abnormal lipid metabolism in the development of type 2 diabetes

2011/12-2016/17 • $375,000
Type 2 diabetes (adult onset diabetes) affects between 7 and 10 percent of the Canadian population and is a major cause of mortality and suffering from heart disease, stroke, amputations, blindness, and renal failure. Its prevalence in our country is increasing due to the epidemics of obesity...

GSK-CIHR Endowed Chair in Optimal Management of Chronic Disease

2012/13-2016/17 • $200,000
The basis for the proposed program of research is to significantly extend and enhance, both in terms of scope and methodology, the projects and initiatives in which the applicant has been involved in the recent years. This will be accomplished by conducting original research, building capacity,...

Studies on Hepatitis B and Hepatitis C in a Unique Mouse Model for Viral Hepatitis

2010/11-2015/16 • $375,000
Hepatitis B virus (HBV) and hepatitis C virus (HCV) are the primary causes of chronic viral hepatitis that can lead to end-stage liver disease (cirrhosis) or hepatocellular carcinoma. There is an estimated 400 million chronic carriers of HBV and 170 to 200 million chronic carriers of HCV....

Chronic Obstructive Pulmonary Disease (COPD) induced cardiovascular disease

2010/11-2015/16 • $322,790
Chronic obstructive pulmonary disease (COPD) or better known as Chronic Bronchitis & Emphysema, is a progressive inflammatory condition of the lungs predominantly causes by cigarette smoke and air pollution. COPD is a worldwide public health problem has been projected to be the 3rd leading cause...

GSK-CIHR Endowed Chair in Clinical Pharmacology

2011/12-2015/16 • $225,000
Serious drug side effects (Adverse Drug Reactions or ADRs) are both common and important problems in treatment of children. How these reactions occur is poorly understood. The goal for the CIHR-GSK Chair in Paediatric Clinical Pharmacology is to study the question of how ADRs occurs in order to...

Defining the structural basis for LXR beta antagonism

2014/15-2015/16 • $126,664
Synthetic glucocorticoids (GCs) are among the most widely prescribed drugs in the world. Glucocorticoid drugs have profound anti-inflammatory and immunosuppressive properties that are critical for treating a wide variety of chronic conditions including rheumatoid arthritis and inflammatory bowel...

20/20: NSERC Ophthalmic Materials Network

2010/11-2014/15 • $4,220,600
Vision, arguably the most critical of the senses, is dependent on healthy ocular tissues. Unfortunately, disease, aging and congenital defects affect the health of these tissues. 20/20: NSERC Network for the Development of Advanced Opthalmic Materials brings together 11 Canadian researchers from...

Overcoming antibiotic resistance through the inhibition of aminoglycoside phosphotransferases (APH).

2013/14-2014/15 • $169,101
Multidrug resistant microbes have become one of the top global health challenges and place a massive burden on theCanadian health care system. One approach to overcome this problem involves inhibiting the enzymes responsible forconferring resistance to the antibiotic. We have recently discovered...

Homeostasis in autonomic functions: seeking therapeutic targets in diseases of aging

2010/11-2014/15 • $112,500
A significant area of the brain is involved in the moment-to-moment control of vital physiological functions, many of which fluctuate over the day-night period, and are beyond our conscious experience. Examples include arterial blood pressure, blood glucose, energy-related and stress-related...

cAMP-Dependent gene transactivation: a novel mechanism underlying the anti-inflammatory activity of PDE4 inhibitors in COPD.

2012/13-2014/15 • $56,250
Chronic obstructive pulmonary disease (COPD) is a chronic disease of the lungs that includes bronchitis (excessive mucus production) & emphysema (lung destruction). COPD takes a long time to develop, affects middle aged and elderly people and is caused, usually, by chronic cigarette smoking....

Vitamin D vs placebo in the prevention of viral-induced exacerbations in preschool aged children with asthma – a pilot RCT

2013/14-2014/15 • $41,250
Asthma is the most common chronic condition affecting Canadian children. More than one in ten children in Canada suffer with asthma. Insufficient Vitamin D levels are also becoming more prevalent in Canada due to the low level of sun exposure. Interestingly, Vitamin D levels are even lower in...

Platform technologies for podocyte in vitro cultivation

2014/15 • $25,000
In this project, we will use techniques from microfabrication, soft lithography and polymer science to create an in vitro environment that enables the kidney cells, podocytes, to acquire their native phenotype. Such microfabricated environment does not exist. Instead, podocytes are cultivated in...

Canadian Cohort Obstructive Lung Disease (CanCOLD)

2011/12-2013/14 • $1,108,844
Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in Canada. People with COPD, the umbrella term for chronic bronchitis and emphysema, often don't get the care they need because of a lack of knowledge of the diseases among both physicians and patients in addition...

Manufacturing of bioactive molecules using digital microfluidics

2011/12-2013/14 • $528,000
This strategic grant application aims to enable manufacturing of a challenging class of molecules. The plan is to build on a collaboration between the labs of Andrei Yudin and Aaron Wheeler at the University of Toronto and to develop a capability to manufacture macrocyclic peptides using digital...

Empowering Patients as Active Partners in Their Care: Lupus Interactive Navigator (LIN)

2011/12-2013/14 • $245,578
Lupus is a disease with no cure with chronic fatigue and inflammation and a greater risk of disability. A typical person with lupus is a young woman taking on average 5-8 medications, with doses that may vary from visit to visit. The risk of confusion is great and there has not been, to date,...

Mechanisms of antiviral drug resistance in seasonal and pandemic influenza strains and evaluation of new therapeutic modalities

2011/12-2013/14 • $228,975
Influenza viruses constitute a serious threat to mankind through yearly epidemics affecting 10-20% of the Canadian population and occasional pandemics as shown by the rapid spread of the pandemic 2009 H1N1 virus throughout the world. Besides general public health measures and vaccines,...

Using the zebrafish as a pre-clinical animal tumour model for drug discovery and the evaluation of anti-leukemia agents

2012/13-2013/14 • $199,999
T-cell acute lymphoblastic leukemia (T-ALL) is a high risk subtype of the most common leukemia affecting children. Although intensive chemotherapy treatments have improved survival in this disease, a significant number of patients do not respond to therapy or relapse. For these patients, a...

Skeletal muscle dysfunction in COPD

2010/11-2013/14 • $195,000
Chronic obstructive pulmonary disease (COPD) is highly prevalent and the burden of this disease is only expected to increase in the coming 15-20 years. Once viewed as a disease limited to the lung, COPD is now recognized as a disease involving various organs. The impairment in lower limb muscle...

Immunological mechanisms of therapeutic peptide vaccines in allergic asthma

2010/11-2013/14 • $153,725
Allergic diseases result from an over-reaction of the immune system to normally harmless environmental proteins from house dust, grass pollens and pets. These proteins are called "allergens". The exagerated immune response is controlled by a particular kind of white blood cell called a T cell. T...

Regulation of CRTh2 and its Role in Allergic Disease

2011/12-2013/14 • $131,250
Allergic diseases such as asthma are mediated by a number of cell types, particularly T helper type 2 (Th2) cells and eosinophils. Both these cell types express a protein called CRTh2, which helps them enter the site of allergic inflammation, such as the lung, nose or skin. CRTh2 also regulates...

Medical Annotation of the Human Genome Sequence

2010/11-2013/14 • $117,000
The human genome encodes the information sufficient to direct the development of a fertilized egg into a complex organism capable of decoding its own DNA instruction book. Variation in DNA forms the basis of human diversity and in some instances deleterious changes can occur resulting in...

Medical Annotation of the Human Genome Sequence

2010/11-2013/14 • $87,750
The human genome encodes the information sufficient to direct the development of a fertilized egg into a complex organism capable of decoding its own DNA instruction book. Variation in DNA forms the basis of human diversity and in some instances deleterious changes can occur resulting in...

Human and Viral Factors Determining HIV Progression and Response to Antiretroviral Therapy

2010/11-2012/13 • $204,167
The research is designed to look at HIV evolves in response to the highly active therapies that have been so successful in treating people infected with it. Although these therapies have greatly decreased the amount of sickness and death caused by HIV, not everyone responds well to them, and...

Mechanism of action of DNMT1 inhibitors; a pharmacoepigenomic analysis

2010/11-2012/13 • $198,969
All cells contain the same genetic information but different cells in the body are programmed in specific ways so that they can perform their different designated tasks. One machinery that is involved in programming which genes are expressed is the DNA methylation machinery which coats the genes...

ER stress as a two face factor in adaptive immune responses: Checkpoint in lymphocytes development and danger signal in dendritic cells

2011/12-2012/13 • $37,500
The capacity of a cell to produce functional and properly assembled proteins is performed by the endoplasmic reticulum (ER). The proper activity of this organelle is critical for the cell functions. Therefore, regulating mechanisms have evolved and are known as ER stress pathways or Unfolded...

Susceptibility to severe human respiratory syncytial virus infections during early childhood: the role of the innate immune system.

2011/12-2012/13 • $26,719
Lungs are for life. Unfortunately, the most frequent long-term illnesses in children and babies are conditions of the respiratory system. Damage to the lungs of children can have different genetic, developmental, and environmental causes. Respiratory Syncytial Virus (RSV) infections are very...

Epithelium mediated regulation of airway smooth muscle contractile phenotype and function in a tissue engineered airway wall

2010/11-2012/13 • $22,500
The inside of the airways of the human lung are lined by a layer of epithelial cells that are separated by a very small distance from airway smooth muscle cells. In obstructive airway diseases such as asthma the epithelial layer is damaged and increased contraction of the smooth muscle causes...

Uncovering Molecular Pathways Regulating Lung Epithelial Differentiation

2010/11-2012/13 • $22,500
Lung obstructive diseases, asthma, cystic fibrosis, and lung cancer are human pulmonary diseases for which the design of specific treatments is limited by knowledge of both normal and pathologic lung biology. The proposed project aims to understand the processes involved in the formation and...

Therapeutic development of cystic fibrosis correctors

2010/11-2011/12 • $360,000
Cystic fibrosis is the most common fatal genetic disease. It affects at least 80,000 patients worldwide, imposing enormous burdens on the patient, their families and on society. Advances in early detection, antibiotic therapy and care have seen the median age for survival of CF patients increase...

Studies on modulation of the innate immune response to HCV in chimeric mice

2010/11-2011/12 • $131,250
Hepatitis C Virus (HCV) is a major cause of liver disease with an estimated 250,000 HCV carriers in Canada and 170 million worldwide. Approximately 80% of HCV-infected people develop a chronic infection. The 20% of patients that clear the virus likely do so through two branches of the immune...

Canadian Cohort Obstructive Lung Disease (CanCOLD)

2010/11 • $167,467
Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in Canada. COPD is not just a disease of men, nor is it solely a disease in old age. Women have been underrepresented and early disease has not been studied. Underdiagnosis of COPD remains a significant problem,...

Application of the Mouse Model to Evaluate to Cytokine and Selected Small Molecule Antiviral Agents for Hepatitis C

2010/11 • $19,250
Hepatitis C virus causes chronic inflammation of the liver. This inflammation can lead to hardening of the liver (cirrhosis) or cancer of the liver (hepatoma). There are approximately 200,000 Canadians infected with Hepatitis C virus. There is no vaccine and today's recognized treatment with...

The role of Apical Junction Complexes in airway epithelial repair and differentiation in asthma

2010/11 • $11,250
Asthma is a serious world-wide public health problem with the Global Initiative for Asthma (GINA) reporting that as many as 300 million people world wide have the disease. Although much is known about the allergic inflammatory events that occur during an asthma attack little is known about the...

No IP found. Try a different search.