ANTI-CRISPR INHIBITORS

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Contact University of Toronto

Inventors
Documents
Applicants
  • THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
  • University of Toronto

Abstract

The present disclosure provides compositions and methods for introducing or enhancing Aca activity in prokaryotic cells. The provided compositions and methods can be used to inhibit Acr activity in prokaryotic cells, thereby enhancing endogenous or exogenous CRISPR-Cas activity. Cells, polynucleotides, plasmids, phage, and other elements for practicing the present methods are also provided.