METHODS, COMPOSITIONS AND KITS FOR THE ASSESSMENT OF MILD COGNITIVE IMPAIRMENT

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  • Institut national de la recherche scientifique

Abstract

Methods, compositions and kits for the assessment and management of mild cognitive impairment (MCI) and early stage Alzheimer's disease (AD), and to monitor changes in cognitive functions in subjects over time, are described. The assessment for MCI and early stage AD is based on the level of BDNF, NSE, S100B, PGRN and/or the PGRN/BDNF ratio, in plasma-derived extracellular vesicles (EVs) from a subject.