- PERSANO, Stefano,
- STOJDL, David
- Children's Hospital of Eastern Ontario Research Institute
- University of Ottawa
A lipid nanoparticle composition is disclosed. The lipid nanoparticle composition includes: a core, and a lipid mixture encapsulating the core. The core includes: (i) a complex of a poly-(beta-amino ester) polymer with DNA or RNA; or (ii) a peptide. The lipid mixture encapsulating the core includes: (a) N1-[2-((1S)-1-[(3-aminopropyl)amino]-4-[di(3-amino-propyl)amino]butylcarboxamido)ethyl]-3,4-di[oleyloxy]-benzamide (MVL5); (b) 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE); and (c) a polyethylene glycol (PEG)-modified lipid. Uses and methods associated with the lipid nanoparticle composition are also disclosed.