T CELL RECEPTORS AND METHODS OF USE THEREOF

Inventors
  • HIRANO, Naoto,
  • MURATA, Kenji,
  • SASO, Kayoko
Documents
Applicants
  • University Health Network
Contact Info
Mark Taylor
Director, Technology Development & Commercialization
(416) 581-7404
[email protected]

Abstract

The present disclosure is directed recombinant T cell receptors capable of binding an NY-ESO-1 epitope and nucleic acid molecules encoding the same. In some embodiments, the nucleic acid molecules further comprise a second nucleotide sequence, wherein the second nucleotide sequence or the polypeptide encoded by the second nucleotide sequence inhibits the expression of an endogenous TCR. Other aspects of the disclosure are directed to vectors comprising the nucleic acid molecule and cells comprising the recombinant TCR, the nucleic acid molecule, or the vector. Still other aspects of the disclosure are directed to methods of using the same. In some embodiments, the methods comprise treating a cancer in a subject in need thereof.