MODULATORS OF AMPA RECEPTOR SIGNALING

Inventors
  • GREIG, Iain,
  • LIU, Fang
  • SMITH, Stephen Allan,
  • TSENG, Chih-Chung
  • ZANATO, Chiara,
  • ZHAI, Dongxu,
Documents
Applicants
  • Centre for Addiction and Mental Health
  • THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN
Contact Info
Klara Vichnevetski
Director, Industry Partnerships and Technology Transfer Office
(416) 535-8501 ext. 36056
[email protected]

Abstract

The present disclosure relates to compounds of the Formula (I) which have shown utility in modulating AMPA receptor signaling and thus preventing AMPA receptor-mediated toxicity, which may find use in the treatment of diseases in which AMPA receptor activation plays a role in neurodegeneration, including the treatment of multiple sclerosis and other diseases.