BISPHENOL DERIVATIVES AND THEIR USE AS ANDROGEN RECEPTOR ACTIVITY MODULATORS

Inventors
  • ANDERSEN, RAYMOND
  • SADAR, MARIANNE DOROTHY
  • JIAN, KUNZHONG
  • MAWJI, NASRIN
  • WANG, JUN
  • BANUELOS, CARMEN ADRIANA
  • YANG, YU-CHI
Documents
Applicants
  • British Columbia Cancer Agency
  • University of British Columbia
Contact Info
Brett Sharp
Associate Director Technology Transfer
(604) 822-8588
[email protected]

Abstract

Compounds having a structure of Formula I or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, R11a, R11b, R11c, R11d, and X, are as defined herein, are provided. Uses of such compounds for modulating androgen receptor activity, imaging diagnostics in cancer and therapeutics, and methods for treatment of subjects in need thereof, including prostate cancer are also provided.