METHODS AND DEVICES FOR ANALYZING PARTICLES

Contacts

Contact University of British Columbia

Inventors
  • HANSEN, CARL LARS GENGHIS
  • ZAHN, HANS
  • HUFT, JENS
  • VAN LOENHOUT, MARINUS THEODORUS JOHANNES
  • LEUNG, KASTON
  • LIN, BILL KENGLI
  • KLAUS, ANDERS
  • APARICIO, SAMUEL ALVES JANA RODRIGUES
  • SHAH, SOHRAB PRAKASH
  • STEIF, ADI
Documents
Applicants
  • University of British Columbia

Abstract

Methods, devices and systems for analyzing precious samples of cells, including single cells are provided. The methods, devices, and systems in various embodiments of the invention are used to assess genomic heterogeneity, which has been recognized as a central feature of many cancers and plays a critical role in disease initiation, progression, and response to treatment. The methods devices and systems are also used to analyze embryonic biopsies for reimplantation genetic diagnosis (PGD). In one embodiment, the devices, systems and methods provided herein allow for the construction of genomic and RNA-seq libraries without a pre-amplification step.