14-3-3 eta antibodies and uses thereof for the diagnosis and treatment of arthritis

Inventors
  • MAROTTA, Anthony
Documents
Applicants
  • KILANI, RUHANGIZ
  • MAROTTA, ANTHONY
  • University of British Columbia
  • GHAHARY, AZIZ
  • MAKSYMOWYCH, WALTER, WOLODYMYR, PETER
Contact Info
Brett Sharp
Associate Director Technology Transfer
(604) 822-8588
[email protected]

Abstract

14-3-3 eta antibodies and uses thereof for the diagnosis and treatment of arthritis are provided. The invention provides anti-14-3-3 eta antibodies that specifically bind to the human 14-3-3 eta protein isoform in its natural configuration while exhibiting selectivity over human 14-3-3 alpha, beta, delta, epsilon, gamma, tau, and zeta protein isoforms. Methods, kits and pharmaceutical compositionscomprising said specific anti-14-3-3 eta antibodies are further provided for the diagnosis and treatment of arthritis.