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Latest Additions
Patent
  • University Health Network

The invention provides novel anti-TSG-6 antibodies, pharmaceutical compositions comprising such antibodies, and therapeutic methods of using such antibodies and pharmaceutical compositions for the treatment of diseases such as cancer or autoimmune disease.

Added: 2020-09-17
Patent
  • Children's National Medical Center
  • Echigoya, Yusuke
  • ECHIGOYA, Yusuke
  • University of Alberta

The disclosure relates to compositions comprising a nucleotide sequence having two domains: a locked nucleic acid domain and a DNA gap domain, wherein nucleotide sequence binds to an endogenous DUX4 mRNA sequence disrupts DUX4 expression.

Added: 2020-09-17
Patent
  • Governors of the University of Alberta
  • Massachusetts Institute of Technology
  • University of Alberta

The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.

Added: 2020-09-17
Patent
  • University of Alberta

The present disclosure relates to 2-(3 -indolyl)indolin-3 -one derivatives of the natural product isatisine A, synthesized from dual catalytic synthesis on metalocarbene-azide cascade chemistry, useful for treating a subject having or suspected of having an infectious disease, wherein said...

Added: 2020-09-17
Patent
  • University of Alberta

A device for replacing a mitral valve includes a substantially cylindrically-shaped body having a top portion, a bottom portion, and a waist portion disposed therebetween and having ferromagnetic elements arranged circumferentially, and the top portion, waist...

Added: 2020-09-17
Patent
  • Dalhousie University

Generating a plan for radiation treatment of multiple target volumes such as, for example, multiple brain tumors, involves optimizing a grouping of the target volumes into subsets and generating treatment plans for each subset. Resulting treatment...

Added: 2020-09-16
Patent
  • Dalhousie University

The present invention provides a method for removing a tattoo in a region of skin the method comprises administering to a least a portion of the tattoo a composition comprising an effective amount of a bisphosphonate and at least one pharmaceutically acceptable...

Added: 2020-09-14
Patent
  • Sangamo Therapeutics France
  • TXCELL
  • University of British Columbia

The present invention relates to a novel anti-HLA-A2 antibody, and to a chimeric antigen receptor comprising said HLA-A2 antibody. The present invention further relates to an immune cell expressing said chimeric receptor antigen, and to therapeutic uses thereof, in particular...

Added: 2020-09-10
Patent
  • University Health Network

The present disclosure is directed recombinant T cell receptors capable of binding an NY-ESO-1 epitope and nucleic acid molecules encoding the same. In some embodiments, the nucleic acid molecules further comprise a second nucleotide sequence, wherein the second nucleotide...

Added: 2020-09-10
Patent
  • University Health Network

The present disclosure is directed recombinant T cell receptors capable of binding an gp100 epitope and nucleic acid molecules encoding the same. In some embodiments, the nucleic acid molecules further comprise a second nucleotide sequence, wherein the second nucleotide...

Added: 2020-09-10
Patent
  • Laval University

A spatial parallel mechanism comprises a platform. Three or more legs configured for extending from a base or ground to the platform, each leg has a distal link, one or more distal joint providing one rotational degree of freedom (DOF) about a distal rotational...

Added: 2020-09-10
Patent
  • Centre for Addiction and Mental Health
  • THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN

The present disclosure relates to compounds of the Formula (I) which have shown utility in modulating AMPA receptor signaling and thus preventing AMPA receptor-mediated toxicity, which may find use in the treatment of diseases in which AMPA receptor activation plays a role in...

Added: 2020-09-10
Patent
  • CDRD Ventures
  • Centre for Drug Research and Development
  • University of British Columbia

Provided are humanized anti-HLA-A2 antibodies. In certain aspects, the humanized anti-HLA-A2 antibodies are capable of constituting an antigen binding domain of a chimeric antigen receptor (CAR), where the CAR is capable of being expressed in a human cell such that the...

Added: 2020-09-10
Patent
  • University of British Columbia

and their potential utility in catalyzing α-alkylation of secondary amine-containing moieties.

Added: 2020-09-10
Patent
  • TEAGASC, THE AGRICULTURE AND FOOD DEVELOPMENT AUTHORITY
  • University of Alberta

A method for preparing a kefir product involves providing bacterial strains selected from Acetobacter, Leuconostoc, Lactococcus, or Lactobacillus; providing yeast strains selected from Pichia, Saccharomyces, Kazachstania, or Kluyveromyces; adding the bacterial and yeast...

Added: 2020-09-10
Patent
  • University Health Network

The present disclosure is directed recombinant T cell receptors capable of binding a gp100 epitope and nucleic acid molecules encoding the same. In some embodiments, the nucleic acid molecules further comprise a second nucleotide sequence, wherein the second nucleotide sequence...

Added: 2020-09-10
Patent
  • DANSKA, JAYNE
  • DICK, JOHN
  • Hospital for Sick Children
  • JIN, LIQING
  • PRASOLAVA, TATIANA
  • THEOCHARIDES, ALEXANDRE
  • University Health Network
  • WANG, C. Y., JEAN

PROBLEM TO BE SOLVED: To provide a method for treating a hematological cancer, preferably a leukemia selected from acute lymphocytic leukemia, acute myeloid leukemia, chronic lymphocytic leukemia, chronic myelogenous leukemia,...

Added: 2020-09-10
Patent
  • University Health Network

The present disclosure is directed recombinant T cell receptors capable of binding a gp100 epitope and nucleic acid molecules encoding the same. In some embodiments, the nucleic acid molecules further comprise a second nucleotide sequence, wherein the second nucleotide sequence...

Added: 2020-09-10
Patent
  • University Health Network

The present disclosure is directed recombinant T cell receptors capable of binding an NY-ESO-1 epitope and nucleic acid molecules encoding the same. In some embodiments, the nucleic acid molecules further comprise a second nucleotide sequence, wherein the second nucleotide...

Added: 2020-09-10
Patent
  • Children's Hospital of Eastern Ontario Research Institute
  • University of Ottawa

A lipid nanoparticle composition is disclosed. The lipid nanoparticle composition includes: a core, and a lipid mixture encapsulating the core. The core includes: (i) a complex of a poly-(beta-amino ester) polymer with DNA or RNA; or (ii) a peptide. The lipid mixture encapsulating the core includes:...

Added: 2020-09-10

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