Methods for determining molecular concentration using solid-state nanopores are provided. The methods include measuring a current signal and using the signal to identify first and second electrical signatures. A first set is used to determine a first rate of a...
Described are methods for generating a reporter molecule in response to a target analyte in a cell-free system. A synthetic biological circuit is used to modify the level of the reporter molecule in response to...
Methods and techniques for fabricating layered structures, such as capacitive micromachined ultrasound transducers, as well as the structures themselves. The layered structure has a membrane that includes a polymer-based layer and a top electrode on the polymer-based...
An immunogenic glycan compound has a poly-β-1,4-ManNAc repeating-unit structure variably modified with 6-linked phosphoethanolamine and 6-linked phosphoglycerol.
The App4Independence (A4i) addresses the complexity of support, isolation and relapse risk along the schizophrenia care continuum. A4i is an evidence-based, digital therapeutic intervention (DTx) (mobile app and clinician dashboard) with a regulatory pathway, patent pending features and early...
Alpha Cog Inc. is a neuroscience pharma spin off company developing small molecules for the treatment of cognitive symptoms in depression. Its lead compound is a first in class novel small molecule in late pre-clinical development...
Our scientists have developed a mobile app to objectively assess and encourage motivated behaviour, specifically goal-directed activity, which involves setting and completing plans and goals. The app allows for geo-location sensing that captures real-world behaviour and...
eGuru is a digital health intervention to administer cognitive behavioral therapy (CBT) though a mobile app. eGuru includes a suite of tools that can address a variety of problems ranging from anger to psychotic symptoms and is based in an existing CBT based self-help intervention that has been...
Compounds of general formula or salts or prodrugs thereof, are provided and described herein. The compounds are useful to expand hematopoietic stem cell and/or hematopoietic progenitor cell populations....
There is provided a method of profiling a tumour, the method comprising determining a relative proportion for each of 96 mutation types, wherein the 96 mutation types are defined as the six possible sequence changes C>A, C>G, C>T, T>A, T>C, or T>G in the context of each of...
The present application discloses biofunctional surfaces that have self-assembled monolayers of fluorine groups with "built-in" functional groups promote targeted cell and biomolecule binding to the surface while...
There is provided systems and methods for generating 3D structure estimation of at least one target from a set of 2D Cryo-electron microscope particle images. The method includes: receiving the set of 2D particle images of the target from a...
The present invention provides methods for classifying and for evaluating the prognosis of a subject having breast cancer are provided. The methods include prediction of breast cancer subtype using a supervised algorithm trained to stratify subjects on the basis...
Methods, compositions and uses for inhibiting the growth in blood cancer cells in a patient with one or more of a caffeic acid phenpropyl ester (GL8) analogue selected from the group consisting of As26, J229, J91, LL27, LL23, HM7, As25, MT26, and J205. The...
Methods, devices and systems for analyzing precious samples of cells, including single cells are provided. The methods, devices, and systems in various embodiments of the invention are used to assess genomic heterogeneity, which has been recognized as a central feature of many...
The present disclosure provides methods and compositions that find use in identifying presence of an advanced stage autoimmune liver disease (ALD) is a subject diagnosed as having ALD. Also provided here are methods and compositions that find use in monitoring effectiveness of...
A system and method for controlling the delivery of ultrasound energy to a subject is provided. In particular, such a system and method are capable of safely disrupting the blood-brain barrier. Ultrasound energy is delivered to produce cavitation of an...
Heptose-1-monophosphate-7-derivatives are modifiable immunomodulators that can be used to prepare clinically active conjugate compounds. Such conjugate compounds are useful in modulating an immune response in a subject.
The invention relates to a novel highly selective and potent NPP1 inhibitors, compositions comprising such, and their use as pharmaceuticals.
This application relates to compounds of Formula (I): [targeting peptide]-N(R1)-X1(R2)L1-[linker]-RX n1 (I). The targeting peptide is cyclo[L-Phe-L-Tyr-L-Lys(iPr)-D-Arg-L-2-Nal-Gly-D-Glu]-L-Lys(iPr). R1 is H or methyl. X1 is an optionally substituted...
